Showing posts with label faculty grants. Show all posts
Showing posts with label faculty grants. Show all posts

Thursday, August 21, 2008

A 'Booster Rocket' For Research in the 'Big Tomato'

The headline talks about the "dark side" of stem cells, but the piece was a bit of good news for the University of California, Davis, and particularly one man there who just won $2.2 million from the California stem cell agency.

Reporter Carrie Peyton Dahlberg of The Sacramento Bee reported this week about Paul Knoepfler(pictured), a scientist who recently received a faculty award grant from CIRM that he calls a "booster rocket" that will nearly double the budget of his lab.

Dahlberg wrote:
"His target is a gene that causes tumors – and that can transform adult skin cells into versatile stem cells similar to those in embryos."
She said his hope is to make potential stem cell therapies safer. Knoepfler was quoted as saying,
"I'm very optimistic. I don't think the hurdles we're facing are insurmountable."
Dalhberg also quoted Meri Firpo of the University of Minnesota and Joseph Wu of Stanford, commenting favorable on Knoepfler's work.

The Bee piece triggered one reader remark on its website that expressed appreciation for an objective report. The anonymous commentator said it was one of the few articles that have addressed the cancer risk involved in stem cell therapies.

UC Davis has received $38 million from CIRM during the last three years. The dean of its medical school, Claire Pomeroy, is listed as one of the 100 most powerful persons in Sacramento (along with Gov. Schwarzenegger) by Sacramento magazine. Pomeroy is also one of the 29 directors of the state stem cell agency.

Interestingly, she is not quoted either in The Bee article or the press release from UC Davis on Knoepfler. We assume that is the result of her own choice. Probably a good position to take considering the conflict of interest issues surrounding all the many academic and research executives who sit on the CIRM board and whose employers have benefited to the tune of hundreds of millions of dollars handed out by CIRM.

(Editor's note: For those of you unfamiliar with California geography, Davis is just west of Sacramento, where the UC Davis medical school is actually located. Sacramento is sometimes known as the Big Tomato because of the vast amounts of tomatoes that are grown in the area. In years past, the Sacramento River would run red in the summer from tomato waste from processing plants.)

Wednesday, August 13, 2008

$59 Million Bonanza For California Stem Cell Researchers

Twenty-three California scientists hit it big today when the California stem cell agency awarded them grants that totaled as much as $3.2 million each.

In all, directors of the agency gave away $59 million in its second round of Faculty Awards, which are designed to support "young" researchers and develop more talent in the area of human embryonic stem cell research,.

The grants will support the recipients for as long as five years. They come at a time when competition for grants at the federal level is increasingly competitive. In a news release, CIRM Chairman Robert Klein noted that the average age of a researcher receiving his first grant from the National Institutes of Health is 43. Presumably, today's CIRM recipients are younger, but the agency did not specify their average age in its news release, which contains the names of the recipients and their institutions.

Grant reviewers decided 20 grants were unequivocally worth funding. Directors added three more from the second tier of applications, which reviewers say are worth approving if funds are available. Nine more grants remain in that category and will be considered at next month's directors meeting. A final vote will also be held then on the 22 applications not recommended for funding by reviewers. Fifty-four applications were received.

Today's grants come on top of a similar round approved last December. CIRM gave away $54 million then to 22 scientists. However, that round was tainted by conflict of interest violations by some CIRM directors, that caused the agency to reject 10 applications. Directors then decided to go ahead with another round of Faculty Award grants.

Initially CIRM budgeted $41 million for 14 recipients in the latest round of Faculty Awards. CIRM did not explain the rationale for increasing the program in its news release today.

(Editor's note: This item originally contained a sentence noting that CIRM's original press release said there were 55 applications although internally the numbers totalled 54. We queried CIRM about the matter. CIRM said that 55 was a mistake and that only 54 applications were received.)

Tuesday, March 18, 2008

Strong Interest in $41 Million CIRM Faculty Award Program

The California stem cell agency's effort to boost "young" researchers with grants of up to $2 million has attracted 55 letters of intent, nearly as many as the first round of program last year.

The faculty awards are designed to develop relatively young and promising researchers and particularly physician-scientists at a critical stage in their careers – providing them with salary and research funding for three to five years.

The $41 million grant program comes on top of a similar program last year that drew 59 letters of intent. Ultimately, the agency gave away only $54 million to 22 researchers out of the $85 million allotted in 2007. The grants were curtailed because five CIRM directors violated the agency's conflict-of-interest policies by writing letters on behalf of applicants from their institutions.

CIRM said the letters resulted from an "innocent misunderstanding." CIRM disqualified the 10 applications involved. The directors involved suffered no CIRM penalty, although some reportedly took steps to ease the economic or professional pain of applicants who were affected.

In December, CIRM directors ordered up a second round of faculty awards in order to give another chance to applicants disqualified last year because of their deans' conflict violations.

The names of the institutions and researchers submitting letters of intent this month were not disclosed by CIRM, which keeps them secret. Only the winning applicants names are released and then only after they are approved for funding.

In response to a query, Don Gibbons, chief communications officer for CIRM, released the number of intent letters and said 31 institutions were represented. He did not provide a breakdown for numbers from academic institutions and nonprofit research organizations.

CIRM has directed applicants in the second round not to disclose whether they competed in the first. Disclosing such information in this round could mean disqualification of the applicant.

Grant reviewers, however, are not likely to have too much trouble identifying applicants who are making their second run – unless their latest applications are totally different than the first or the reviewers' memories are faulty.

Fourteen grants are expected to be approved this summer following a closed-door review of the applications by the same CIRM panel that reviewed the first round of the grants. Scientists on that panel do not have to publicly disclose their financial or professional interests. Instead their disclosures are made privately to CIRM.

The application deadline is April 3, although no one can apply unless a letter of intent has already been sent.

Sunday, January 06, 2008

The Cerberus and The Scientist


Leanne Jones watches fruit flies. John M. Simpson watches the Oversight Committee of the California stem cell agency.

Both Jones (see photo) and Simpson came together on Sunday in an article about the scientist and the watchdog by Bradley J. Fikes on the North County Times in the San Diego area.

Fikes wrote about their different perspectives on the $3 billion research effort that has come to be so important in their lives. In the case of Jones, the Oversight Committee last month approved a $2.7 million grant for Jones and her work at the Salk Institute.

Fikes wrote,
"'Early on in your career, you have all these ideas, and you have to be very focused because your funds are so limited,' Jones said. 'Since I started my lab, I've had to spend a considerable amount of time writing grants to try to fund the lab once my initial funding from the Salk ran out. That meant that I could do very little in the way of "hands-on" experiments.

"'This CIRM grant gives me enough of a base so that I don't have to write grants for a while, which means I can spend more time in the lab actually doing the experiments, rather than just talking or writing about them. ... This is going to be fun.'"
As for Simpson, he described his role as a constructive effort to make sure that taxpayers get what they pay for and to ensure that CIRM research benefits the public at a price that people can afford. Simpson also noted that his organization, the Foundation for Taxpayer and Consumers Rights, has acted to remove impediments to stem cell research in general, citing the challenges to the stem cell patents held by WARF.

Saturday, January 05, 2008

CIRM Directors Meet to Mull More Faculty Awards, Mega Millions for Labs

Coming up in the middle of this month is the $263 million California stem cell lab construction bonanza, but some other items are also up for consideration by directors of the state's stem cell agency.

CIRM has posted the agenda for the two-day session beginning Jan. 16. Besides the largest round of grants in CIRM history, the Oversight Committee is scheduled to take up a proposal to "make whole" -- sort of -- the 10 scientists who suffered as a result of breaches of CIRM's conflict of interest policy by the deans of their medical schools.

No details are yet available on the posted agenda, but CIRM plans to offer a new round of faculty award grants. Initial discussions indicated that it would be open to all (with qualifications)– not just the those who were dumped from last month's $54 million round.

Also on the agenda are compensation changes, travel policy and new plans for conferences and meetings. Some of those will mean increased spending, although no details are yet available on the CIRM website.

As for the "Mega Millions Jackpot" – whoops, that is another California state program -- for lab construction, if CIRM holds to past practice, sometime between now and Jan. 16, we should see the postings on the public summaries of the grant reviews for 12 institutions that were anointed earlier. Given the complexity of the proposals and staff turnover at CIRM, we would expect to see the summaries later rather than earlier, which would make it difficult for the public or other interested parties to review them and prepare comments for the Oversight Committee meeting.

Thursday, January 03, 2008

CIRM Moves to Refocus Public Debate

The outgoing and incoming presidents of the California stem cell agency published a piece in the San Jose Mercury News today defending the agency, declaring that the state's taxpayers should be proud of CIRM's efforts.

The op-ed article was written by Richard Murphy, interim president of CIRM, and Alan Trounson, who is the new permanent president.

In it, they point to the recent $54 million in grants to scientists as a sign that the CIRM is doing well. Little is new in the piece, but it represents an effort by CIRM to refocus public discussion of the agency in a more positive light following weeks of more negative news coverage.

Thursday, December 13, 2007

'Great to be in California' Says Recipient of $2.2 Million Stem Cell Grant



News coverage of Wednesday's California stem cell agency meeting – with its $54 million in research grant awards and conflict-of-interest flap – was light today.

Only one newspaper reporter attended the meeting along with one TV and one radio reporter. However, other newspapers picked up the story remotely, including Terri Somers of the San Diego Union-Tribune.

She focused on the grants going to San Diego area area researchers, along with quotes from recipients. She wrote:
"Lei Wang(see photo), 35, an assistant professor in Salk's Chemical Biology and Proteomics Laboratory, will receive $2.6 million for his proposal to develop new technologies for the precise investigation of molecular events in stem cells.

"Although his proposal was scored the highest of all 49 considered, Wang said it would not have been granted funding by the NIH. What the regenerative medicine institute's scientific reviewers found to be 'bold and exceptionally innovative' would be considered too risky by the NIH, he said.

"David Traver(see photo), 38, an assistant professor of biological sciences at UCSD, will receive about $2.2 million for research into how stem cells of the blood-forming system are generated.

"'It's great to be in California,' Traver said. "My colleagues in the field are envious of this amazing thing the taxpayers of California have done.'"
Wang's comment will resonate at CIRM, which wants to encourage research that will break out of the mainstream.

The only newspaper reporter at the meeting was Bradley Fikes of the North County Times of San Diego County. He wrote:
"Leaders of California's $3 billion stem cell program struggled with a rash of alleged conflict of interest problems Wednesday, even as they awarded $54.4 million in grants to 22 young scientists."
Meanwhile, in a column in The Sacramento Bee on Tuesday, longtime political columnist Dan Walters mentioned the California stem cell agency in a discussion of "unseemly activities" at some of "semi-public, semi-private fiefdoms" that exist in state government.

He touched on the problems with the state's First 5 California Children and Families Commission and Rob Reiner and wrote:.
"A more current example is another agency also created by ballot measure and headed by the man who sponsored the campaign, the Institute for Regenerative Medicine, which has $3 billion in state bond funds to finance stem cell research.

"From its onset three years ago, the agency has been managed by businessman Robert Klein as a secretive, quasi-private pot of money that would be disbursed by mysterious procedures. It's especially troublesome that many of those serving on the agency's board are heads of universities and other institutions seeking research grants. It's another scandal waiting to happen."
Walters's perspective is one that would be more common among reporters who might write about CIRM should the agency surface with a higher level controversy.

In addition to Los Angeles TV station KTLA, John Brooks of KFWB radio covered the CIRM meeting on Wednesday. Here are links to the stories by Jim Downing of The Sacramento Bee and Steve Johnson of the San Jose Mercury News.

Wednesday, December 12, 2007

Names of Faculty Award Recipients

Here is a link to the CIRM news release on the names and the institutions of the faculty award recipients. http://www.cirm.ca.gov/press/pdf/2007/12-12-07.pdf

CIRM Hands Out $54 Million to Researchers

Directors of the California stem cell agency today approved $54 million in grants to fund some of the brightest young researchers in the state.

The amount fell far short of the $85 million originally scheduled for the faculty award program. The amount was reduced largely because of violations of the agency's conflict of interest code by five of its directors.

Deans at four medical schools and one research institution wrote letters on behalf of the applications. CIRM then rejected the 10 applications that were affected. It appeared that seven of them would likely have been funded.

Directors also told CIRM staff to prepare another grant proposal for consideration in January that will give the 10 affected scientists another chance. CIRM Chairman Robert Klein said additional funds should be added to that round.

CIRM staff said such a round would be treated as completely new. Others rejected on Wednesday would have a chance to compete again. Applications could be revised. New scientific reviews will be conducted.

CIRM also released the names of the institutions that submitted "tainted" applications: UCLA, UCSF, USC, UCSD and the Burnham Institute. All except Burnham had been identified by sources earlier.

John M. Simpson, stem cell project director for the Foundation for Taxpayer and Consumer Rights, praised the release of the names, but said they should have come earlier. He said,
"Holding back the details simply undermines the public’s trust in the stem cell agency. I don’t understand their propensity for secrecy. It serves neither the board nor the agency nor the public."
Names of the institutions and researchers receiving the grants today had not been released by CIRM at the time of this writing.

Saturday, December 08, 2007

CIRM Deflecting Away From Directors on Conflict Problems

The San Diego Union-Tribune, The Sacramento Bee, San Francisco Chronicle and the San Jose Mercury News carried stories today on the conflict-of-interest flap at the California stem cell agency and the rejection of a 10 grant applications seeking perhaps $25 million.

Notably missing from the coverage was the Los Angeles Times, the largest newspaper in the state, which had two of its local institutions, UCLA and USC, lose applications. CIRM put out a news release on the problem on Friday after the story was broken by Russell Sabin of the San Francisco Chronicle. The issue involves violation of the agency's conflict of interest policy by members of its board of directors who wrote letters in support of the application.

CIRM's news release and subsequent comments by agency spokespersons pointed away from the directors and towards language in the application, which required letters of support from either the dean of the applicant's institution or the departmental head.

At least two of today's stories noted that other institutions with members on the CIRM filed applications without violating conflict of interest rules.

Jim Downing of the Bee wrote:
"Claire Pomeroy, dean of the UC Davis School of Medicine, sits on the agency's board. Her school's applicants were not hit by Friday's action because their letters of recommendation were written by an associate dean.

"'We have a very clear barrier,' said UC Davis School of Medicine spokesman Charles Casey. "(Pomeroy) did not even know who we were submitting for those faculty grant awards."
Terri Somers of the San Diego Union-Tribune reported that Salk and Burnham both reported no problems with their applications. Stanford apparently is okay as well. All three have representatives on the CIRM board.

Somers also provided an update on the conflict of interest problem involving John Reed, president of the Burnham Institute, and his attempt to influence a grant last summer. She wrote:

"Board member and AIDS activist Jeff Sheehy said he is not clamoring for Reed's resignation, but he wants an acknowledgment that there was a 'serious violation of an important rule.'

"'My problem is that we are acting like nothing happened,' Sheehy said.

"He has asked for a discussion of the matter to be placed on the agenda for the meeting Wednesday.

"Also that day, the board will decide what to do with the remaining 49 faculty grant applications. It could vote to award all or some of the grant money. Or it could decide to toss out the entire grant round and start over."

Besides The Bee and San Diego, here are links to the stories in the Chronicle and Mercury News.

(Editor's note: An earlier version of this story carried the figure $15 million in the first paragraph. The actual figure appears to be closer to $25 million.)

Friday, December 07, 2007

CIRM Rejects Grant Applications in Wake of Director Conflicts

The California stem cell agency, already under fire because of one conflict-of-interest flap, today dumped 10 applications for grants of up to $3 million annually as the result of additional violations of its conflict of interest policy by members of its board of directors.

The announcement followed a report in the San Francisco Chronicle (see below) this morning that disclosed the problems with grant applications from UC San Francisco, UC San Diego, UCLA and the University of Southern California.

The newspaper said that applications from those institutions included letters of support from the deans of those schools who also sit on the board of directors for the $3 billion program. Members of the board of directors are barred from attempting to influence a decision regarding a grant.

CIRM's announcement did not mention conflicts of interests. Nor did it mention the names of the schools, which may submit more than one application on behalf of their researchers. It also did not indicate whether more institutions than the four were involved.

The problems are connected to an $85 million faculty award program aimed at supporting top-flight, young researchers for several years. CIRM said that with the rejection of the 10 applications, the size of the program could shrink by about $15 million. Awards are scheduled to be approved by directors next week in Los Angeles.

Interim CIRM President Richard Murphy said that "checks and balances" at CIRM detected the problem. According to the Chronicle, CIRM staffers identified the conflicts. Murphy said the problem was the result of an "innocent misunderstanding."

CIRM Chairman Robert Klein said steps will be taken to prevent a recurrence of similar problems. They include more review of applications prior to issuance, special guidance to board directors and "specific guidance on access to counsel" concerning applications.

Klein, an attorney, was involved in the earlier conflict problem involving the Burnham Institute. He advised John Reed, a CIRM director and president of the Burnham, to write a letter in August lobbying CIRM staff to overturn a negative decision on a grant to Burnham. The case has attracted international attention online in scientific journals and has generated a call for an investigation by the California Fair Political Practices Commission.

John M. Simpson, stem cell project director for the Foundation for Taxpayer and Consumer Rights, said CIRM made the right decision in rejecting the 10 applications. But he said in a news release:
"The only way to fix this is complete transparency. People have a right to know which board members still don’t understand conflict of interest rules."
Simpson continued:
"It’s simple: stem cell board members cannot take part in any way in grants to their institutions. The board is not some old-boys’ club for the benefit of the state’s universities. They are public officials and stewards of the public interest. Perhaps a few of these deans need to enroll in Ethics 101 at their universities and get the basics down."

Both Simpson and California's top fiscal officer, state Controller John Chiang, have called for the FPPC investigation in the Burnham case.

The Chronicle said that applications for the faculty award grants required a letter of support signed by the dean of the medical school or the departmental chair.

In addition to the four schools identified by the Chronicle, other institutions have top academic officials, including deans, represented on CIRM's board. They include Stanford, UC Davis and UC Irvine. CIRM refuses to disclose the names of institutions that apply for grants on the grounds that those rejected might be embarrassed.

However, it is reasonable to assume that at least one of those three schools applied for the faculty award program and did not submit a letter that would be a conflict of interest.

In response to a question from the California Stem Cell Report, Simpson said,
"They need to make clear what institutions and board members are involved. And they need use the words "conflict of interest violation. Even if they don't do that, the (CIRM news) release was gobbledygook."
Murphy, also in response to questions, said that all 10 applications were eliminated for the same reason. He said,
"ICOC members and CIRM staff are, like all government officials, aware of and sensitive to conflict of interest concerns. This is precisely why CIRM has acted so cautiously in this case. The concerns about the submissions in response to the new faculty (awards)arose out of an innocent misunderstanding of what was allowable in terms of the sign off of institutional support letters by ICOC members."
Jesse Reynolds of the Center for Genetics and Society, writing on the organization's blog Biopolitical Times, said, the Burnham conflict case and today's suggest "a board culture that does not take conflicts of interest seriously. The picture seems even sharper in light of CIRM board members' personal financial interests in companies that are invested in stem cell research, documented in a CGS report in April 2005."

Reynolds continued,
"This meddling is symptomatic of the deep flaws of Proposition 71, which created CIRM. It mandates that the CIRM board be dominated by high-ranking representatives of the institutions vying to maximize their slice of the public funding pie. These developments should stimulate the California legislature to alter the law to reform the board structure, and more."

Conflict Problems Snag $85 Million CIRM Grant Program

Applications from four California stem cell powerhouses for CIRM research grants that could run as high as $3 million a year could be in jeopardy because of concerns about conflicts of interest.

Reporter Sabin Russell of the San Francisco Chronicle disclosed the problem today in a story about the $85 million faculty award program. The grants are scheduled to be awarded next week at a meeting in Los Angeles.

The universities involved are the University of California campuses in San Francisco, Los Angeles, San Diego and the University of Southern California. Russell wrote that CIRM may "toss out" the applications because they "included letters of support from deans who also sit on the citizens' board that governs the $3 billion program."

Russell continued,
"Sources close to the grant-making process said that staffers at the California Institute for Regenerative Medicine flagged the applications for conflict-of-interest violations, despite a requirement that each request contain a letter of support 'signed by the Dean or Departmental Chair.'"
Russell wrote,
"Although the grant application called for letters of support from the deans or department chairmen, the conflict-of-interest policy for the stem cell institute also specifies that its board members "shall not make, participate in making, or in any way attempt to use their official position to influence a decision regarding a grant ...'

"Therefore, schools that followed one set of state instructions may well have violated another set of rules - putting at risk millions of dollars in potential research. Institutions not represented on the board, or that had department heads rather than deans write the support letters, avoided the problem.

"The apparent contradiction in the rulebook is the kind of problem that critics say was built into the stem cell initiative passed by voters in 2004. Concerned about avoiding even the appearance of conflicts of interest, the governing board debated its rules extensively during a meeting in April 2005."
CIRM told Russell that it had no comment on the matter nor did the insitutions.

The Chronicle story said,
"It remains unclear what will happen if the grant applications are rejected. One option, according to sources, is to simply have the four universities reapply at a later date - a delay of at least six months. Another option would be to reject all of the grants and have everyone update their applications because of the confusion regarding the letter-of-recommendation rules."
Russell's story came on the heels of the disclosure on this web site of an improper attempt earlier this year by a CIRM director, John Reed, to influence the awarding of a grant to his own insitution, the Burnham Institute.

Russell also reported that David Serrano Sewell, another director, said that Reed should resign. Sewell said,
"I've given a great deal of thought to this. It has nothing to do with his abilities as a scientist. But his continued presence on our board undermines our ability to do our job."
Earlier Reed said he did not intend to resign. But a Burnham spokeswoman told Russell that he had not made a decision.

Friday, October 19, 2007

Position Change: CIRM Now Permitting Public Comment at $85 Million Hearing

The California stem cell agency today reversed itself and decided to permit public comments prior to two days of closed hearings next week on requests for $85 million in grants to California researchers.

The change in position came quietly today as the agency posted a new agenda for the hearings on the CIRM web site that did not mention that it had been revised. The new posting specifically stated that public comment would be allowed. It also removed this sentence from the agenda::
"An open session will not be held for the meeting of October 23-24, 2007 as business will be limited to review of grant applications."
The change in public access followed disclosure earlier today by the California Stem Cell Report of the ban and subsequent complaints by at least one member of the CIRM Oversight Committee, David Serrano Sewell (see item below).

Comment on Ban on Public at $85 Million CIRM Meeting

David Serrano Sewell, a member of the CIRM Oversight Committee, sent the following on the "Public Barred" item below.
"Just read your item regarding the public being barred from the upcoming Grants Working Group meeting. To my recollection, those agendas have always included an opportunity for the public to address the working group. The failure to include such an item for this agenda was probably a honest mistake that must be corrected. I (and the the patient advocate working group members) support the public attendance at working group meetings. Thanks for catching this!"
Our comment: The agenda for the meeting in question contains a sentence that we cannot recall ever seeing before on a CIRM agenda:
"An open session will not be held for the meeting of October 23-24, 2007 as business will be limited to review of grant applications."

Public Barred from Any Comment at $85 Million CIRM Meeting

Two days of closed-door meetings will be held in the San Francisco Bay area next week to consider the 59 applications for $85 million in faculty award grants to be handed out in December by the California stem cell agency.

The agency's Grants Working Group will meet next Tuesday and Wednesday at the Sheraton Gateway Hotel in Burlingame to make decisions on which grants to recommend to the Oversight Committee.

The agenda explicitly states there will be no open sessions at which the public can comment. That bars the public from even appearing to protest or comment on the lack of public access, which seems to be the first such ban by CIRM, an agency that has vowed to uphold the highest standards of openness and transparency. Previously, such meetings, including the very sensitive meetings involving the search for a new president, have included at least a brief session during which the public could comment.

Here is a list of the members of the Working Group, whose economic and professional links to applicants are secret. Also being withheld by CIRM decree are the names of the applicants for the state funding and even the institutions (including state-funded universities) where they are employed along with a general summary of the research they are proposing.

The Oversight Committee is scheduled to give out as many as 25 awards, making the odds pretty good for the 59 applicants. The awards could total as much as $3 million a year. Twenty-eight unnamed organizations are represented among employers of the individual applicants.

Thursday, September 06, 2007

Christmas Coming Early for 25 California Scientists

Fifty-nine "young" California scientists are seeking awards from the California stem cell agency that could run as high as $3 million a year.

CIRM is scheduled to give away $85 million to 25 scientists in December, which should make a fine holiday treat.

Dale Carlson, chief communications officer for CIRM, told the California Stem Cell Report that applications came from researchers at 28 organizations. Eleven University of California and California State University campuses were represented. The California State Univesity system is separate from UC. Four private universities submitted applications. Thirteen non-profit research institutions were included.

The institute refuses to disclose both the names of individual applicants and institutions, even those that are taxpayer-funded enterprises.

The five-year faculty award program is aimed at drawing the best and brightest into stem cell research in California and not just embryonic stem cell research. Arlene Chiu, CIRM's top scientist, said,
“These grants are designed to encourage newly independent investigators to pursue bold and innovative studies across the full range of stem cell types – human and animal, embryonic and adult. We will consider providing successful applicants salary and research funding for up to five years, ensuring that they have stable, secure financial support as they begin their independent scientific careers.”

Friday, August 10, 2007

CIRM Says No to Public Access on Faculty Grants

The California stem cell agency today refused to disclose the names of the institutions whose faculty members are seeking $85 million in public funds.

Dale Carlson, chief communications officer for CIRM, said that the institutions' names would not be disclosed until after the grants are awarded in December. He said the justification for the secrecy was the same as for the secrecy on applications for previous research grants.

Basically CIRM wants to ensure candor in the evaluation of individual research proposals and avoid embarrassing them or damaging their reputations. But CIRM did not make it clear how institutions such as UCLA or Stanford could be embarrassed or harmed by the disclosure that they nominated scientists for the prestigious awards or how the evaluation process could be damaged by such identification.

John M. Simpson, stem cell project director for the Foundation for Taxpayer and Consumers Rights, said that not only should the institutions be named but that the individual scientists also should be publicly identified.

In some ways, CIRM is more open than other more cloistered institutions, such as the NIH, we are told. But in other ways, it remains tightly under wraps.

Comparisons are difficult to make with other government agencies or universities. CIRM, although it is a state agency and operates with state funds, is not subject to the normal gubernatorial or legislative oversight. Operational minutia concerning the agency is codified in state law and cannot be changed without another vote of the people or a super, super-majority vote in the legislature. Such independence does not exist at the University of California or the NIH.

At the same time, the board is rife with conflicts – all entirely legal because they were approved by voters in Prop. 71, which created the agency. Fifteen members of its board of directors, for example, have ties to institutions that could stand to benefit by tens of millions dollars in its latest $227 million lab grant program.

What that means is that CIRM should be more, rather than less open in order to maintain public confidence in its worthy endeavors.

Fifty-nine Scientists Reach for CIRM's Golden Ring

The odds do not appear to be too bad in the California stem cell agency's new and generous $85 million faculty award program. It could make 25 stem cell researchers quite happy this holiday season.

Fifty-nine persons filed letters of intent to apply for the awards that could run as high as $3 million annually. CIRM could give out as many as 25 grants, if it decides it has that many worthy candidates. That, of course, means one out of 2.36 applicants could be funded.

The scientists come from 29 California institutions, whose names were not immediately disclosed. We have asked for the names of the institutions and will carry CIRM's response when it is forthcoming.

CIRM's press release today said,
"New Faculty Awards will fund the research of promising M.D. and Ph.D. scientists in their early years as independent lead investigators and faculty members. They are intended to develop a new generation of clinical and scientific leaders in stem cell research.

"While previous CIRM research grants focused on human embryonic stem cell research, the New Faculty Awards will support research across the full range of stem cell types – human and animal, adult and embryonic."
The schedule calls for the awards to be approved at the board's December meeting. The deadline for applications is Aug. 30 but those who did not file letters of intent are out of luck. Between now and then, the applications will be reviewed behind closed doors by a group of out-of-state scientists and some members of the CIRM Oversight Committee, who have filed public economic disclosure statements. However, the scientists involved in the review do not have to file public statements. They file secret economic disclosure statements with CIRM. Their private statements are also aimed at identifying potential professional conflicts.

Wednesday, July 18, 2007

Nature Magazine Trumpets California 'Upstart'

The California stem cell agency's $85 million faculty awards program received some attention today on the website of Nature magazine.

A brief piece by Monya Baker noted that the program had been announced by "an upstart state-funded initiative to make California a stem-cell research hub."

She wrote:
"US biomedics moving from postdoc to independent research often struggle to find stable sources of funding. New investigators receive only 6% of US National Institutes of Health (NIH) R01 awards, the multi-year grants that US universities rely on. Similar to R01, the CIRM grants will fund direct project costs of $300,000 for academics and $400,000 for clinicians. Worries over money hamper long-term thinking, says Xianmin Zeng of the Buck Institute in Novato, California, who plans to apply. Many foundations give only small amounts of money over one or two years, she says. 'For young investigators to get a stable environment, they need a stable foundation,' Zeng says."

Friday, June 29, 2007

CIRM Faculty Awards Deadline in August

The big day – at least a day some scientists will not want to miss -- for the handsome faculty awards from the California stem cell agency is Aug. 9.

That is when the letters of intent are due from applicants for the $85 million program, which will provide salary and research support for up to five years for 25 California stem cell scientists. Arlene Chiu, CIRM’s interim chief scientific officer, said,

"These grants are designed to encourage newly independent investigators to pursue bold and innovative studies across the full range of stem cell types – human and animal, embryonic and adult. We will consider providing successful applicants salary and research funding for up to five years, ensuring that they have stable, secure financial support as they begin their independent scientific careers."

The awards are scheduled to be approved in December with cash actually coming next spring.

CIRM's press release can be found here. The RFA here. And an earlier item on the program here.

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