Directors of the California stem cell today launched a $34 million effort to create a string of Alpha stem cell clinics intended to make the Golden State the leading spot globally for stem treatments
and research.
The winners of $8 million grants each were the City of Hope
in Duarte, Ca.; the University of California, San Diego, and UCLA, whose proposal included UC Irvine. Three applications were rejected including those from Cedars-Sinai and UC Davis, which appealed an earlier negative reviewer decision. Action on a fourth application was delayed because of an unspecified allegation of a conflict-of-interest during the closed-door review process.
(Here is a link to the CIRM press release.)
(Here is a link to the CIRM press release.)
Upcoming in a grant round next year will be creation
of a related, $10 million Alpha data and information center that would be both a central repository
for research and an education/marketing effort for patients and the public.
The concept for
the one-stop centers was first offered in 2011 by former agency President Alan
Trounson, who resigned earlier this year to return to Australia. Nature Medicine reported that the Alpha clinics would be the first-ever “clinical trials network focused around a broad therapeutic platform.”
The Alpha proposal was originally budgeted at $70 million with up to five
Alpha clinics including a $15 million information center. However, there was no requirement that all five
awards be made.
Earlier this year, Randy Mills, the new president of the
California Institute for Regenerative Medicine (CIRM), as the agency is
formally known, successfully recommended slicing $5 million from the data
center. The proposal is now being recast.
Each of the winners is contributing considerable resources
to the Alpha plan along with two clinical trials. The nature of those
contributions and their size was not disclosed to the public or the directors. Seven applications were considered by reviewers with some including more than one major institution.
Afflictions targeted by the winning institutions range from cancer and heart disease to diabetes and spinal cord injury. The effort is part of CIRM’s push
to fulfill the promises of the ballot campaign of 2004 that created the agency.
The drive to produce actual treatments is also critical to
generating fresh financial support for CIRM, which is expected to run out of
cash in about 2020. It currently relies on money that the state is borrowing
and that flows directly to the agency without going through the normal
budgetary process.
Today’s action included cuts in the research budgets proposed by the
winners, who sought $11 million to $11.7 million each. Instead the board put a
cap of $8 million on the grants. The cuts came after concerns were raised about
duplication of costs and inclusion of expenses related to the proposed
data/information center.
The nature of each grant’s budget changes will be subject to
negotiations with members of the agency’s team.
Here are links to selected, previous items on the Alpha
clinic plan:
TUESDAY, MAY 28, 2013
Alan
Trounson, president of the California stem cell agency, this summer
plans to seek $70 million for creation of what he calls Alpha Clinics,
high-powered organizations that will fast-track stem cell therapies to
patients.
WEDNESDAY, MAY 29, 2013
In addition to the comments filed online in connection with the $70 million proposal to create Alpha Clinics in California for stem
cell treatments, two other readers commented privately in
emails.
One came from a close observer of the stem cell agency who said,
“If done right -- and I'm sure you and I agree that is a big 'if' – it could be
an outstanding legacy.”
The
other comment came from a physician-researcher at a major California
institution and was longer and more critical.
MONDAY, JULY 22, 2013
Want to know more about the business aspects of a $70 million
proposal to create a chain of“Alpha” stem cell clinics in
California?
More
details can be found in a report from the California stem cell agency titled “Alpha Stem Cell Clinics: Delivering a New Kind of Medicine.”
WEDNESDAY, JULY 24, 2013
California's
$70 million plan for a chain of “Alpha” stem cell clinics today received its
first major attention from the mainstream media.
TUESDAY, FEBRUARY 04, 2014
A $70
million race was kicked off last month as the California stem cell agency
invited eight institutions to compete to create what it calls
Alpha Clinics, enterprises that would attract patients from throughout
the world for stem cell therapies.
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