$500,000 to Fight Covid-19 from California's Stem Cell Program

The California stem cell agency on Friday awarded a total of $500,000 to two UCLA scientists to help in the fight against Covid-19, including early stage research aimed at boosting the immune response of older persons. 

The grants are part of a $5 million, "emergency" Covid round that is aimed at fast-tracking promising research. 

Song Li (left) and Vaithilingaraja
Arumugaswami, UCLA photos

Vaithilingaraja Arumugaswami

received $350,000 for work dealing with Berzosertib, a therapy targeting viral replication and damage in lung stem cells. 

Arumugaswami said in a UCLA news release, 

"Clinical trials have shown that Berzosertib blocks the DNA repair pathway in cancer cells, but has no effects on normal, healthy cells. For this reason, we think this drug shows great promise for treating COVID-19 patients and could be rapidly and safely be deployed in the clinic."

A summary of reviewer comments on his application (TRAN1COVID19-11975) can be found here. 

Song Li received $150,000 to help develop an injectable biomaterial that can induce the formation of T memory stem cells, which are important in generating an immune response. 

Li said that if his work is successful, it could have applications well beyond Covid-19. A summary of reviewer comment on his application (DISC2COVID) can be found here. 

Directors of the agency rejected six applications in their action on Friday. Summaries of all application reviews can be found here. 

The stem cell agency, which is running out cash, is now supporting 11 Covid-19 projects, including two clinical trials. The fast-track Covid round is accepting applications every two weeks. More awards are expected when agency directors meet again on June 26. 

The agenda at that time will include other matters such as the budget for the coming 12 months, including a wind-down schedule should voters reject a $5.5 billion ballot measure to refinance the agency, which is running out of money. 

  

Click on this sentence to see the agency's press release on last week's awards. 

California's $5.5 Billion Stem Cell Countdown: Total Now up to Nearly 540,000

California county elections officials have been tallying
signatures on stem cell initiative petitions for one month.

Nearly 27,000 signatures were added today as the $5.5 billion effort to rescue the California stem cell agency moved slowly towards an all-but-assured position on the November ballot

The proposed ballot initiative is aimed at saving the agency from its financial demise. The 15-year-old program is running out of cash and will begin closing its doors in the fall without more funds. 

Earlier this week, the California Stem Cell Report analyzed the trends in the tally, concluding that qualification is in the "virtual bag." 

Today's figures from state officials showed 537,558 verified signatures of registered voters, up from yesterday's 510,930. The campaign is hoping for 685,534. The qualification rate is steady at about 78 percent. If the qualification rate stays fractionally above 67 percent, the measure will be placed on the ballot.  

Look for the next update on the count Monday evening or early Tuesday on the California Stem Cell Report, your only independent source of information and news about the stem cell agency for the last 15 years.

California's $5.5 Billion Stem Cell Countdown: Campaign Not Likely To Sue for Deadline Extension

Solano County contributed 7,670 signatures this afternoon to the snail-like progress of a $5.5 billion stem cell research proposal towards a virtually assured position on the November ballot.

The measure is aimed at saving the California stem cell agency from fiscal extinction. The 15-year-old program is running out of cash and will begin closing its doors in the fall without more funds. 

Earlier this week, The California Stem Cell Report analyzed the trends in the count, concluding that qualification is in the "virtual bag." 

Today's figures from state officials showed 510,930 verified signatures of registered voters, up from yesterday's 503,260. The campaign is hoping for 685,534. The qualification rate is steady at about 78 percent. If the qualification rate stays fractionally above 67 percent, the measure will be placed on the ballot.  

Only 14 counties out of 58 have not filed their verification numbers.

If the stem call initiative comes up short, it could join the effort to force the state to extend the deadline. Two groups have already sued seeking more time. One effort involves sports betting at Native American casinos. The other involves data privacy. The basic argument is that the Covid-19 crisis seriously and unexpectedly hampered the signature gathering which is constitutionally protected process. 

However, in response to a query, campaign spokeswoman  Sarah Melbostad today said,

"We have been pleased with the validity rates we’ve seen so far and are still confident that we are going to qualify for the November 2020 ballot. We have no plans to join these lawsuits or to file our own."

Look for the next update on the count tomorrow evening or early Saturday on the California Stem Cell Report, your only independent source of information and news about the stem cell agency for the last 15 years.

California's $5.5 Billion Stem Cell Countdown: Inching Towards November 3

San Francisco stepped up today to provide 10,900 signatures to help the California stem cell agency refinance itself through a $5.5 billion initiative that is headed for the November ballot. 

What's at stake is qualifying the proposal so that it will be presented to voters in the fall. Earlier this week, The California Stem Cell Report analyzed the trends in the count, concluding that qualification is in the "virtual bag." 

Today's figures from state officials showed 503,260 verified signatures of registered voters, up from yesterday's 492,349 . The campaign is hoping for 685,534. The qualification rate is steady at about 78 percent. If the qualification rate stays fractionally above 67 percent, the measure will be placed on the ballot.  

Only 15 counties out of 58 have not filed their verification numbers. For stem cell history buffs, San Francisco, once known as Baghdad by The Bay, also was once known as the home of the stem cell agency for a number of years. The city won the headquarters in a bidding war after it promised $18 milion, including 10 years in free rent. The agency moved to Oakland when the free rent ran out because of the high cost of office space in San Francisco.

California Gov. Gavin Newsom was then mayor of San Francisco and played a major role in reeling in the stem cell agency. He has not spoken publicly about whether he supports the $5.5 billion initiative. 

Look for the next update on the count tomorrow evening or early Friday on the California Stem Cell Report, your only independent source of information and news about the stem cell agency for the last 15 years.

California's $5.5 Billion Stem Cell Countdown: The Official Tally Creeps Towards the Certainty of November

Watching the Signature Numbers

* The campaign is seeking 110 percent of the
legal requirement of 623,212 to avoid going to a 
prolonged full check. Sources: Secretary of State
June 9, 2020, California Stem Cell Report

The $5.5 billion initiative to save the California stem cell agency from its financial demise today made more slow progress in the official state count that is nearly certain to qualify it for the November ballot. 

The numbers already show that the measure is headed for the ballot unless something extremely unusual occurs. The California Stem Cell Report yesterday  analyzed the trends in the signature count, concluding that qualification is in the "virtual bag." 

Today's figures from state officials showed 492,349 verified signatures of registered voters, up from 484,973 on Monday. The campaign is hoping for 685,534. The qualification rate is steady at about 78 percent. If the qualification rate stays fractionally above 67 percent, the measure will be placed on the ballot.  

Only 16 counties out of 58 have not filed their verification numbers.

Look for the next update on the count tomorrow evening or early Thursday on the California Stem Cell Report, your only independent source of information and news about the stem cell agency for the last 15 years.

Editor's note: An earlier version of this item said Monday's count of verified signatures was 481,689, which is actually from Friday. The correct figure for Monday is 484,973.